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Myocardial Extracellular Volume Quantification by Cardiovascular Magnetic Resonance and Computed Tomography

Scully, PR; Bastarrika, G; Moon, JC; Treibel, TA; (2018) Myocardial Extracellular Volume Quantification by Cardiovascular Magnetic Resonance and Computed Tomography. Current Cardiology Reports , 20 (3) , Article 15. 10.1007/s11886-018-0961-3. Green open access

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Abstract

PURPOSE OF REVIEW: This review article discusses the evolution of extracellular volume (ECV) quantification using both cardiovascular magnetic resonance (CMR) and computed tomography (CT). RECENT FINDINGS: Visualizing diffuse myocardial fibrosis is challenging and until recently, was restricted to the domain of the pathologist. CMR and CT both use extravascular, extracellular contrast agents, permitting ECV measurement. The evidence base around ECV quantification by CMR is growing rapidly and just starting in CT. In conditions with high ECV (amyloid, oedema and fibrosis), this technique is already being used clinically and as a surrogate endpoint. Non-invasive diffuse fibrosis quantification is also generating new biological insights into key cardiac diseases. CMR and CT can estimate ECV and in turn diffuse myocardial fibrosis, obviating the need for invasive endomyocardial biopsy. CT is an attractive alternative to CMR particularly in those individuals with contraindications to the latter. Further studies are needed, particularly in CT.

Type: Article
Title: Myocardial Extracellular Volume Quantification by Cardiovascular Magnetic Resonance and Computed Tomography
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1007/s11886-018-0961-3
Publisher version: http://doi.org/10.1007/s11886-018-0961-3
Language: English
Additional information: Copyright © The Author(s) 2018 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
Keywords: Cardiovascular magnetic resonance, Computed tomography, Extracellular volume, Tissue characterization
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Institute of Cardiovascular Science
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Institute of Cardiovascular Science > Clinical Science
URI: http://discovery.ucl.ac.uk/id/eprint/10045349
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