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Neural and Aneural Regions Generated by the Use of Chemical Surface Coatings

Pardo-Figuerez, M; Martin, NRW; Player, DJ; Capel, AJ; Christie, SDR; Lewis, MP; (2018) Neural and Aneural Regions Generated by the Use of Chemical Surface Coatings. ACS Biomaterials Science and Engineering , 4 (1) pp. 98-106. 10.1021/acsbiomaterials.7b00663. Green open access

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The disordered environment found in conventional neural cultures impedes various applications where cell directionality is a key process for functionality. Neurons are highly specialized cells known to be greatly dependent on interactions with their surroundings. Therefore, when chemical cues are incorporated on the surface material, a precise control over neuronal behavior can be achieved. Here, the behavior of SH-SY5Y neurons on a variety of self-assembled monolayers (SAMs) and polymer brushes both in isolation and combination to promote cellular spatial control was determined. APTES and BIBB coatings promoted the highest cell viability, proliferation, metabolic activity, and neuronal maturation, while low cell survival was seen on PKSPMA and PMETAC surfaces. These cell-attractive and repulsive surfaces were combined to generate a binary BIBB-PKSPMA coating, whereby cellular growth was restricted to an exclusive neural region. The utility of these coatings when precisely combined could act as a bioactive/bioinert surface resulting in a biomimetic environment where control over neuronal growth and directionality can be achieved.

Type: Article
Title: Neural and Aneural Regions Generated by the Use of Chemical Surface Coatings
Open access status: An open access version is available from UCL Discovery
DOI: 10.1021/acsbiomaterials.7b00663
Publisher version: http://doi.org/10.1021/acsbiomaterials.7b00663
Language: English
Additional information: © 2017 American Chemical Society. ACS AuthorChoice - This is an open access article published under a Creative Commons Attribution (CC-BY) License, which permits unrestricted use, distribution and reproduction in any medium, provided the author and source are cited.
Keywords: Cell behavior; polymer brushes; SAMs; SH-SY5Y
URI: http://discovery.ucl.ac.uk/id/eprint/10045158
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