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The Skin and Parkinson's Disease: Review of Clinical, Diagnostic, and Therapeutic Issues

Skorvanek, M; Bhatia, KP; (2017) The Skin and Parkinson's Disease: Review of Clinical, Diagnostic, and Therapeutic Issues. Movement Disorders , 32 (1) pp. 21-31. 10.1002/mdc3.12425.

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Abstract

Background Parkinson's disease (PD) and the skin are related in a number of ways, including clinical abnormalities of the disease itself and skin-related side effects of dopaminergic medication, pumps, and surgical therapies. Recent advances in understanding the role of α-synuclein suggest skin biopsies as a potential diagnostic or even a premotor marker of PD. Methods The PubMed database was searched for publications up to October 2015, and the current evidence on skin-related issues in PD was comprehensively summarized. Results The evidence was summarized on the prevalence, etiology, and management of seborrheic dermatitis, sweating dysfunctions, bullous pemphigoid, and malignant melanoma, as well as therapy-related skin disorders, especially those observed in amantadine, rotigotine, apomorphine, and levodopa/carbidopa intestinal gel therapies and deep-brain stimulation. Skin biopsies evaluating the presence of α-synuclein, the density and morphology of cutaneous nerves, and skin fibroblast functions also are discussed. Conclusions Skin disorders are a common manifestation of PD. However, the exact pathophysiology and prevalence of these disorders are not well understood, and more systematic research is needed in this regard. Peripheral tissue biopsies as a diagnostic marker of PD are an exciting avenue in future PD research, although multiple caveats and pending issues need to be solved before they can be used in routine clinical practice.

Type: Article
Title: The Skin and Parkinson's Disease: Review of Clinical, Diagnostic, and Therapeutic Issues
DOI: 10.1002/mdc3.12425
Publisher version: https://doi.org/10.1002/mdc3.12425
Language: English
Additional information: This version is the version of record. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Science & Technology, Life Sciences & Biomedicine, Clinical Neurology, Neurosciences & Neurology, alpha-synuclein, melanoma, Parkinson's disease, skin, therapy, DEEP BRAIN-STIMULATION, PERCUTANEOUS ENDOSCOPIC GASTROSTOMY, DUODENAL LEVODOPA INFUSION, ALPHA-SYNUCLEIN PATHOLOGY, MALIGNANT-MELANOMA, LIVEDO-RETICULARIS, NONMOTOR SYMPTOMS, NEUROLOGICAL DISEASES, MITOCHONDRIAL DYSFUNCTION, AUTONOMIC FUNCTION
URI: http://discovery.ucl.ac.uk/id/eprint/10045095
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