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Chapter Forty-Six - Nonmotor Features in Atypical Parkinsonism

Bhatia, KP; Stamelou, M; (2017) Chapter Forty-Six - Nonmotor Features in Atypical Parkinsonism. International Review of Neurobiology , 134 pp. 1285-1301. 10.1016/bs.irn.2017.06.001.

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Atypical parkinsonism (AP) comprises mainly multiple system atrophy (MSA), progressive supranuclear palsy (PSP), and corticobasal degeneration (CBD), which are distinct pathological entities, presenting with a wide phenotypic spectrum. The classic syndromes are now called MSA-parkinsonism (MSA-P), MSA-cerebellar type (MSA-C), Richardson's syndrome, and corticobasal syndrome. Nonmotor features in AP have been recognized almost since the initial description of these disorders; however, research has been limited. Autonomic dysfunction is the most prominent nonmotor feature of MSA, but also gastrointestinal symptoms, sleep dysfunction, and pain, can be a feature. In PSP and CBD, the most prominent nonmotor symptoms comprise those deriving from the cognitive/neuropsychiatric domain. Apart from assisting the clinician in the differential diagnosis with Parkinson's disease, nonmotor features in AP have a big impact on quality of life and prognosis of AP and their treatment poses a major challenge for clinicians.

Type: Article
Title: Chapter Forty-Six - Nonmotor Features in Atypical Parkinsonism
Location: United States
DOI: 10.1016/bs.irn.2017.06.001
Publisher version: https://doi.org/10.1016/bs.irn.2017.06.001
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Atypical parkinsonism, Autonomic, Cognition, Corticobasal degeneration, Multiple system atrophy, Nonmotor features, Progressive supranuclear palsy
URI: http://discovery.ucl.ac.uk/id/eprint/10045091
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