Galimov, E;
Pryor, R;
POOLE, S;
Benedetto, A;
Pincus, Z;
Gems, D;
(2018)
Coupling of Rigor Mortis and Intestinal Necrosis During C. elegans Organismal Death.
Cell Reports
, 22
(10)
pp. 2730-2741.
10.1016/j.celrep.2018.02.050.
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Abstract
Organismal death is a process of systemic collapse whose mechanisms are less well understood than those of cell death. We previously reported that death in C. elegans is accompanied by a calcium-propagated wave of intestinal necrosis, marked by a wave of blue autofluorescence (death fluorescence). Here, we describe another feature of organismal death, a wave of body wall muscle contraction, or death contraction (DC). This phenomenon is accompanied by a wave of intramuscular Ca2+ release and, subsequently, of intestinal necrosis. Correlation of directions of the DC and intestinal necrosis waves implies coupling of these death processes. Long-lived insulin/IGF-1-signaling mutants show reduced DC and delayed intestinal necrosis, suggesting possible resistance to organismal death. DC resembles mammalian rigor mortis, a postmortem necrosis-related process in which Ca2+ influx promotes muscle hyper-contraction. In contrast to mammals, DC is an early rather than a late event in C. elegans organismal death.
| Type: | Article |
|---|---|
| Title: | Coupling of Rigor Mortis and Intestinal Necrosis During C. elegans Organismal Death |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.celrep.2018.02.050 |
| Publisher version: | https://doi.org/10.1016/j.celrep.2018.02.050 |
| Language: | English |
| Additional information: | Copyright © 2018 The Author(s). This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
| Keywords: | aging, ATP, calcium, C. elegans, muscle, necrosis, organismal death, pathology, rigor mortis |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Genetics, Evolution and Environment |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10044243 |
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