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Determinants of long-term outcome in ICU survivors: results from the FROG-ICU study

Gayat, E; Cariou, A; Deye, N; Vieillard-Baron, A; Jaber, S; Damoisel, C; Lu, Q; ... Mebazaa, A; + view all (2018) Determinants of long-term outcome in ICU survivors: results from the FROG-ICU study. Critical Care , 22 , Article 8. 10.1186/s13054-017-1922-8. Green open access

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Background Intensive care unit (ICU) survivors have reduced long-term survival compared to the general population. Identifying parameters at ICU discharge that are associated with poor long-term outcomes may prove useful in targeting an at-risk population. The main objective of the study was to identify clinical and biological determinants of death in the year following ICU discharge. Methods FROG-ICU was a prospective, observational, multicenter cohort study of ICU survivors followed 1 year after discharge, including 21 medical, surgical or mixed ICUs in France and Belgium. All consecutive patients admitted to intensive care with a requirement for invasive mechanical ventilation and/or vasoactive drug support for more than 24 h following ICU admission and discharged from ICU were included. The main outcome measure was all-cause mortality at 1 year after ICU discharge. Clinical and biological parameters on ICU discharge were measured, including the circulating cardiovascular biomarkers N-terminal pro-B type natriuretic peptide, high-sensitive troponin I, bioactive-adrenomedullin and soluble-ST2. Socioeconomic status was assessed using a validated deprivation index (FDep). Results Of 1570 patients discharged alive from the ICU, 333 (21%) died over the following year. Multivariable analysis identified age, comorbidity, red blood cell transfusion, ICU length of stay and abnormalities in common clinical factors at the time of ICU discharge (low systolic blood pressure, temperature, total protein, platelet and white cell count) as independent factors associated with 1-year mortality. Elevated biomarkers of cardiac and vascular failure independently associated with 1-year death when they are added to multivariable model, with an almost 3-fold increase in the risk of death when combined (adjusted odds ratio 2.84 (95% confidence interval 1.73–4.65), p < 0.001). Conclusions The FROG-ICU study identified, at the time of ICU discharge, potentially actionable clinical and biological factors associated with poor long-term outcome after ICU discharge. Those factors may guide discharge planning and directed interventions.

Type: Article
Title: Determinants of long-term outcome in ICU survivors: results from the FROG-ICU study
Open access status: An open access version is available from UCL Discovery
DOI: 10.1186/s13054-017-1922-8
Publisher version: https://doi.org/10.1186/s13054-017-1922-8
Language: English
Additional information: This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
Keywords: Science & Technology, Life Sciences & Biomedicine, Critical Care Medicine, General & Internal Medicine, Post-intensive care syndrome, Long-term survival, Biomarkers, Score, Discharge, QUALITY-OF-LIFE, INTENSIVE-CARE UNITS, CRITICAL ILLNESS, HOSPITAL DISCHARGE, GENERAL-POPULATION, 5-YEAR SURVIVAL, HEART-FAILURE, FOLLOW-UP, MORTALITY, SEPSIS
URI: http://discovery.ucl.ac.uk/id/eprint/10043189
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