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Cerebrospinal fluid neurogranin and TREM2 in Huntington’s disease

Byrne, LM; Rodrigues, FB; Johnson, EB; Da Vita, E; Blennow, K; Scahill, RI; Zetterberg, H; ... Wild, E; + view all (2018) Cerebrospinal fluid neurogranin and TREM2 in Huntington’s disease. Scientific Reports , Article 4260. 10.1038/s41598-018-21788-x. Green open access

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Biomarkers of Huntington’s disease (HD) in cerebrospinal fluid (CSF) could be of value in elucidating the biology of this genetic neurodegenerative disease, as well as in the development of novel therapeutics. Deranged synaptic and immune function have been reported in HD, and concentrations of the synaptic protein neurogranin and the microglial protein TREM2 are increased in other neurodegenerative diseases. We therefore used ELISAs to quantify neurogranin and TREM2 in CSF samples from HD mutation carriers and controls. CSF neurogranin concentration was not significantly altered in HD compared to controls, nor was it significantly associated with disease burden score, total functional capacity or motor score. An apparent increase in CSF TREM2 in manifest HD was determined to be due to increasing TREM2 with age. After age adjustment, there was no significant alteration of TREM2 in either HD group, nor any association with motor, functional or cognitive score, or brain volume quantified by MRI. Both analyses were well-powered, and sample size calculations indicated that several thousand samples per group would be needed to prove that disease-associated alterations do in fact exist. We conclude that neither neurogranin nor TREM2 is a useful biofluid biomarker for disease processes in Huntington’s disease.

Type: Article
Title: Cerebrospinal fluid neurogranin and TREM2 in Huntington’s disease
Open access status: An open access version is available from UCL Discovery
DOI: 10.1038/s41598-018-21788-x
Publisher version: https://doi.org/10.1038/s41598-018-21788-x
Language: English
Additional information: This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
URI: http://discovery.ucl.ac.uk/id/eprint/10043168
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