Shribman, S;
Noyce, A;
Gnanapavan, S;
Lambourne, J;
Harrison, T;
Schon, F;
(2017)
Cryptococcal meningitis in apparently immunocompetent patients: association with idiopathic CD4+ lymphopenia.
Practical Neurology
10.1136/practneurol-2017-001800.
(In press).
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Abstract
We present two cases of cryptococcal meningitis in people subsequently diagnosed with idiopathic CD4+ lymphopenia. Both presented with new onset headaches without sinister features and were sent home on multiple occasions from emergency departments. Cryptococcal meningitis in HIV-negative patients poses major diagnostic and management problems; the associated mortality is 9%-27%. We suggest performing blood and cerebrospinal fluid cryptococcal antigen tests in all people with lymphocytic meningitis.
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