Serrano, LA;
Yang, Y;
Salvati, E;
Stellacci, F;
Krol, S;
Guldin, S;
(2018)
pH-Mediated molecular differentiation for fluorimetric quantification of chemotherapeutic drugs in human plasma.
Chemical Communications
, 54
(12)
pp. 1485-1488.
10.1039/c7cc07668a.
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Abstract
At present, drug dosage is based on standardised approaches that disregard pharmakokinetic differences between patients and lead to non-optimal efficacy and unnecessary side effects. In this work, we demonstrate the potential of pH-mediated fluorescence spectroscopy for therapeutic drug monitoring in complex media. We apply this principle to the simultaneous quantification of the chemotherapeutic prodrug Irinotecan and its active metabolite SN-38 from human plasma across the clinically relevant concentration range, i.e. from micromolar to nanomolar at molar ratios of up to 30 : 1.
| Type: | Article |
|---|---|
| Title: | pH-Mediated molecular differentiation for fluorimetric quantification of chemotherapeutic drugs in human plasma |
| Location: | England |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1039/c7cc07668a |
| Publisher version: | http://dx.doi.org/10.1039/c7cc07668a |
| Language: | English |
| Additional information: | This article is licensed under a Creative Commons Attribution 3.0 Unported Licence (http://creativecommons.org/licenses/by/3.0/). |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Chemical Engineering |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10042376 |
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