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Evolving concepts in dilated cardiomyopathy

Merlo, M; Cannatà, A; Gobbo, M; Stolfo, D; Elliott, PM; Sinagra, G; (2018) Evolving concepts in dilated cardiomyopathy. European Journal of Heart Failure , 20 (2) pp. 228-239. 10.1002/ejhf.1103. Green open access

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Abstract

Dilated cardiomyopathy (DCM) represents a particular aetiology of systolic heart failure that frequently has a genetic background and usually affects young patients with few co-morbidities. The prognosis of DCM has improved substantially during the last decades due to more accurate aetiological characterization, the red-flag integrated approach to the disease, early diagnosis through systematic familial screening, and the concept of DCM as a dynamic disease requiring constant optimization of medical and non-pharmacological evidence-based treatments. However, some important issues in clinical management remain unresolved, including the role of cardiac magnetic resonance for diagnosis and risk categorization and the interaction between genotype and clinical phenotype, and arrhythmic risk stratification. This review offers a comprehensive survey of these and other emerging issues in the clinical management of DCM, providing where possible practical recommendations.

Type: Article
Title: Evolving concepts in dilated cardiomyopathy
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1002/ejhf.1103
Publisher version: https://doi.org/10.1002/ejhf.1103
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Dilated cardiomyopathy, Genetics, Heart failure, Left ventricular reverse remodelling, Risk stratification, Sudden cardiac death
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Institute of Cardiovascular Science
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Institute of Cardiovascular Science > Clinical Science
URI: http://discovery.ucl.ac.uk/id/eprint/10041964
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