Parr, T;
Friston, KJ;
(2018)
The Computational Anatomy of Visual Neglect.
Cerebral Cortex
, 28
(2)
pp. 777-790.
10.1093/cercor/bhx316.
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Abstract
Visual neglect is a debilitating neuropsychological phenomenon that has many clinical implications and—in cognitive neuroscience—offers an important lesion deficit model. In this article, we describe a computational model of visual neglect based upon active inference. Our objective is to establish a computational and neurophysiological process theory that can be used to disambiguate among the various causes of this important syndrome; namely, a computational neuropsychology of visual neglect. We introduce a Bayes optimal model based upon Markov decision processes that reproduces the visual searches induced by the line cancellation task (used to characterize visual neglect at the bedside). We then consider 3 distinct ways in which the model could be lesioned to reproduce neuropsychological (visual search) deficits. Crucially, these 3 levels of pathology map nicely onto the neuroanatomy of saccadic eye movements and the systems implicated in visual neglect.
| Type: | Article |
|---|---|
| Title: | The Computational Anatomy of Visual Neglect |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1093/cercor/bhx316 |
| Publisher version: | https://doi.org/10.1093/cercor/bhx316 |
| Language: | English |
| Additional information: | © The Author 2017. Published by Oxford University Press. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/). |
| Keywords: | active inference, Bayesian, visual neglect, neuropsychology, saccades |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Imaging Neuroscience |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10041742 |
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