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Hybrid MR-PET of brain tumours using amino acid PET and chemical exchange saturation transfer MRI

Golay, XGGR; Da Silva, NA; Lohmann, P; Fairney, J; Magill, AW; Oros Peusquens, A-M; Choi, C-H; ... Shah, NJ; + view all (2018) Hybrid MR-PET of brain tumours using amino acid PET and chemical exchange saturation transfer MRI. European Journal of Nuclear Medicine and Molecular Imaging , 45 (6) pp. 1031-1040. 10.1007/s00259-018-3940-4. Green open access

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Abstract

PURPOSE: PET using radiolabelled amino acids has become a promising tool in the diagnostics of gliomas and brain metastasis. Currently, amide proton transfer (APT) chemical exchange saturation transfer (CEST) MR imaging is evaluated for brain tumour imaging. In this hybrid MR-PET study, we compared in brain tumours with 3D data derived from APT-CEST MRI and amino acid PET using O-(2-18F-fluoroethyl)-L-tyrosine (18F-FET). METHODS: Eight patients with gliomas were investigated simultaneously with 18F-FET PET and APT-CEST MRI using a 3T MR-BrainPET scanner. CEST imaging was based on a steady-state approach using a B1 average power of 1μT. B0 field inhomogeneities were corrected and parametric images of magnetisation transfer ratio asymmetry (MTRasym) and differences to the extrapolated semi-solid magnetisation transfer reference method, APT# and nuclear Overhauser effect (NOE#), were calculated. Statistical analysis of the tumour-to-brain ratio of the CEST data was performed against PET data using the non-parametric Wilcoxon test. RESULTS: A tumour-to-brain ratio derived from APT# and 18F-FET presented no significant differences and no correlation was found between APT# and 18F-FET PET data. Distance between local hot spots APT# and 18F-FET were different (average 20 ± 13 mm, range 4 - 45 mm). CONCLUSION: For the first time CEST images were compared with 18F-FET in a simultaneous MR-PET measurement. Imaging findings derived from18F-FET PET and APT CEST MRI seems to provide different biological information. The validation of imaging findings by histological confirmation is necessary, ideally using stereotactic biopsy.

Type: Article
Title: Hybrid MR-PET of brain tumours using amino acid PET and chemical exchange saturation transfer MRI
Open access status: An open access version is available from UCL Discovery
DOI: 10.1007/s00259-018-3940-4
Publisher version: http://doi.org/10.1007/s00259-018-3940-4
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: CEST; APT; 18F-FET PET; hybrid MR-PET; glioma
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Brain Repair and Rehabilitation
URI: http://discovery.ucl.ac.uk/id/eprint/10041189
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