Doshi, A;
Chataway, J;
(2017)
Multiple sclerosis, a treatable disease.
Clinical Medicine
, 17
(6)
pp. 530-536.
10.7861/clinmedicine.17-6-530.
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Abstract
This article reviews our current understanding and modern treatment of multiple sclerosis (MS). MS is a disabling condition resulting in devastating social and economic impacts. As MS can affect any part of the central nervous system, the presentation is often diverse; however, there are key features that can be useful in the clinic. We comment on the diagnostic criteria and review the main subtypes of MS, including clinically isolated syndrome, relapsing remitting MS, secondary progressive MS and primary progressive MS. Although the underlying aetiology of MS is still not known, we summarise those with most evidence of association. Finally, we aim to present treatment strategies for managing the acute relapse, disease-modifying therapies and MS symptoms. This review highlights that progressive MS is an area where there is currently a paucity of available disease-modifying treatments and this will be a major focus for future development.
| Type: | Article |
|---|---|
| Title: | Multiple sclerosis, a treatable disease |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.7861/clinmedicine.17-6-530 |
| Publisher version: | http://doi.org/10.7861/clinmedicine.17-6-530 |
| Language: | English |
| Additional information: | © Royal College of Physicians 2017. All rights reserved. This version is the version of record. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Science & Technology, Life Sciences & Biomedicine, Medicine, General & Internal, General & Internal Medicine, Diagnostic criteria, epidemiology, multiple sclerosis, progressive multiple sclerosis, treatments, DOUBLE-BLIND, FOLLOW-UP, RISK, DISABILITY, TRIAL, CLASSIFICATION, MECHANISMS |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Neuroinflammation |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10040902 |
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