Ecker, S;
Pancaldi, V;
Valencia, A;
Beck, S;
Paul, DS;
(2018)
Epigenetic and Transcriptional Variability Shape Phenotypic Plasticity.
BioEssays
, 40
(2)
, Article 1700148. 10.1002/bies.201700148.
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Abstract
Epigenetic and transcriptional variability contribute to the vast diversity of cellular and organismal phenotypes and are key in human health and disease. In this review, we describe different types, sources, and determinants of epigenetic and transcriptional variability, enabling cells and organisms to adapt and evolve to a changing environment. We highlight the latest research and hypotheses on how chromatin structure and the epigenome influence gene expression variability. Further, we provide an overview of challenges in the analysis of biological variability. An improved understanding of the molecular mechanisms underlying epigenetic and transcriptional variability, at both the intra- and inter-individual level, provides great opportunity for disease prevention, better therapeutic approaches, and personalized medicine.
| Type: | Article |
|---|---|
| Title: | Epigenetic and Transcriptional Variability Shape Phenotypic Plasticity |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1002/bies.201700148 |
| Publisher version: | http://doi.org/10.1002/bies.201700148 |
| Language: | English |
| Additional information: | Copyright © 2017 The Authors. BioEssays Published by WILEY Periodicals, Inc This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
| Keywords: | 3D chromatin structure, DNA methylation, biological noise, chromatin, epigenetics, gene expression, genome architecture, heterogeneity, transcription, variability |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Cancer Bio |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10040577 |
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