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Current use and acceptability of novel diagnostic tests for active tuberculosis: A worldwide survey

Amicosante, M; D Ambrosio, L; Munoz, M; Mello, FCDQ; Tebruegge, M; Chegou, NN; Seghrouchni, F; ... Singh, V; + view all (2017) Current use and acceptability of novel diagnostic tests for active tuberculosis: A worldwide survey. Jornal Brasileiro de Pneumologia , 43 (5) pp. 380-392. 10.1590/s1806-37562017000000219. Green open access

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Abstract

OBJECTIVE: To determine the current use and potential acceptance (by tuberculosis experts worldwide) of novel rapid tests for the diagnosis of tuberculosis that are in line with World Health Organization target product profiles. METHODS: A multilingual survey was disseminated online between July and November of 2016. RESULTS: A total of 723 individuals from 114 countries responded to the survey. Smear microscopy was the most commonly used rapid tuberculosis test (available to 90.9% of the respondents), followed by molecular assays (available to 70.7%). Only a small proportion of the respondents in middle- and low-income countries had access to interferon-gamma-release assays. Serological and lateral flow immunoassays were used by more than a quarter (25.4%) of the respondents. Among the respondents who had access to molecular tests, 46.7% were using the Xpert assay overall, that proportion being higher in lower middle-income countries (55.6%) and low-income countries (76.6%). The data also suggest that there was some alignment of pricing for molecular assays. Respondents stated they would accept novel rapid tuberculosis tests if available, including molecular assays (acceptable to 86.0%) or biomarker-based serological assays (acceptable to 81.7%). Simple biomarker-based assays were more commonly deemed acceptable in middle- and low-income countries. CONCLUSIONS: Second-generation molecular assays have become more widely available in high- and low-resource settings. However, the development of novel rapid tuberculosis tests continues to be considered important by tuberculosis experts. Our data also underscore the need for additional training and education of end users.

Type: Article
Title: Current use and acceptability of novel diagnostic tests for active tuberculosis: A worldwide survey
Open access status: An open access version is available from UCL Discovery
DOI: 10.1590/s1806-37562017000000219
Publisher version: http://dx.doi.org/10.1590/s1806-37562017000000219
Language: English
Additional information: © 2017 Sociedade Brasileira de Pneumologia e Tisiologia. This is an open-access article distributed under the terms of the Creative Commons Attribution License
Keywords: Tuberculosis/diagnosis; Surveys and questionnaires; Income; Mycobacterium tuberculosis/isolation & purification; Molecular diagnostic techniques/methods; Serologic tests/methods
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Respiratory Medicine
URI: http://discovery.ucl.ac.uk/id/eprint/10039617
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