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Autologous Cell Seeding in Tracheal Tissue Engineering

Maughan, EF; Hynds, RE; Proctor, TJ; Janes, SM; Elliott, M; Birchall, MA; Lowdell, MW; (2017) Autologous Cell Seeding in Tracheal Tissue Engineering. Current Stem Cell Reports , 3 (4) pp. 279-289. 10.1007/s40778-017-0108-2. Green open access

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Purpose of Review: There is no consensus on the best technology to be employed for tracheal replacement. One particularly promising approach is based upon tissue engineering and involves applying autologous cells to transplantable scaffolds. Here, we present the reported pre-clinical and clinical data exploring the various options for achieving such seeding. Recent Findings: Various cell combinations, delivery strategies, and outcome measures are described. Mesenchymal stem cells (MSCs) are the most widely employed cell type in tracheal bioengineering. Airway epithelial cell luminal seeding is also widely employed, alone or in combination with other cell types. Combinations have thus far shown the greatest promise. Chondrocytes may improve mechanical outcomes in pre-clinical models, but have not been clinically tested. Rapid or pre-vascularization of scaffolds is an important consideration. Overall, there are few published objective measures of post-seeding cell viability, survival, or overall efficacy. Summary: There is no clear consensus on the optimal cell-scaffold combination and mechanisms for seeding. Systematic in vivo work is required to assess differences between tracheal grafts seeded with combinations of clinically deliverable cell types using objective outcome measures, including those for functionality and host immune response.

Type: Article
Title: Autologous Cell Seeding in Tracheal Tissue Engineering
Location: Switzerland
Open access status: An open access version is available from UCL Discovery
DOI: 10.1007/s40778-017-0108-2
Publisher version: http://dx.doi.org/10.1007/s40778-017-0108-2
Language: English
Additional information: Copyright © The Author(s) 2017. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
Keywords: Autologous cell seeding, Clinical translation, Pre-clinical models, Tissue engineering, Trachea
URI: http://discovery.ucl.ac.uk/id/eprint/10039468
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