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Targeting folate receptor alpha for cancer treatment

Cheung, A; Bax, HJ; Josephs, DH; Ilieva, KM; Pellizzari, G; Opzoomer, J; Bloomfield, J; ... Karagiannis, SN; + view all (2016) Targeting folate receptor alpha for cancer treatment. Oncotarget , 7 (32) pp. 52553-52574. 10.18632/oncotarget.9651. Green open access

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Abstract

Promising targeted treatments and immunotherapy strategies in oncology and advancements in our understanding of molecular pathways that underpin cancer development have reignited interest in the tumor-associated antigen Folate Receptor alpha (FRα). FRα is a glycosylphosphatidylinositol (GPI)-anchored membrane protein. Its overexpression in tumors such as ovarian, breast and lung cancers, low and restricted distribution in normal tissues, alongside emerging insights into tumor-promoting functions and association of expression with patient prognosis, together render FRα an attractive therapeutic target. In this review, we summarize the role of FRα in cancer development, we consider FRα as a potential diagnostic and prognostic tool, and we discuss different targeted treatment approaches with a specific focus on monoclonal antibodies. Renewed attention to FRα may point to novel individualized treatment approaches to improve the clinical management of patient groups that do not adequately benefit from current conventional therapies.

Type: Article
Title: Targeting folate receptor alpha for cancer treatment
Open access status: An open access version is available from UCL Discovery
DOI: 10.18632/oncotarget.9651
Publisher version: http://dx.doi.org/10.18632/oncotarget.9651
Language: English
Additional information: This is an Open Access article licensed under a is licensed under a Creative Commons Attribution 3.0 License (http://creativecommons.org/licenses/by/3.0/).
Keywords: folate receptor alpha, cancer, biomarker, monoclonal antibodies, immunotherapy
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Pathology
URI: http://discovery.ucl.ac.uk/id/eprint/10039090
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