UCL logo

UCL Discovery

UCL home » Library Services » Electronic resources » UCL Discovery

Capillary pericytes mediate coronary no-reflow after myocardial ischaemia.

O'Farrell, FM; Mastitskaya, S; Hammond-Haley, M; Freitas, F; Wah, WR; Attwell, D; (2017) Capillary pericytes mediate coronary no-reflow after myocardial ischaemia. elife , 6 , Article e29280. 10.7554/eLife.29280. Green open access

[img]
Preview
Text
elife-29280-v2.pdf - ["content_typename_Published version" not defined]

Download (3MB) | Preview

Abstract

After cardiac ischaemia, a prolonged decrease of coronary microvascular perfusion often occurs even after flow is restored in an upstream artery. This 'no-reflow' phenomenon worsens patient prognosis. In the brain, after stroke, a similar post-ischaemic 'no-reflow' has been attributed to capillary constriction by contractile pericytes. We now show that occlusion of a rat coronary artery, followed by reperfusion, blocks 40% of cardiac capillaries and halves perfused blood volume within the affected region. Capillary blockages colocalised strongly with pericytes, where capillary diameter was reduced by 37%. The pericyte relaxant adenosine increased capillary diameter by 21% at pericyte somata, decreased capillary block by 25% and increased perfusion volume by 57%. Thus, cardiac pericytes constrict coronary capillaries and reduce microvascular blood flow after ischaemia, despite re-opening of the culprit artery. Cardiac pericytes are therefore a novel therapeutic target in ischaemic heart disease.

Type: Article
Title: Capillary pericytes mediate coronary no-reflow after myocardial ischaemia.
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.7554/eLife.29280
Publisher version: http://dx.doi.org/10.7554/eLife.29280
Language: English
Additional information: © 2017 eLife Sciences Publications Ltd. Subject to a Creative Commons Attribution license, except where otherwise noted. This version is the version of record. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Cell biology, human biology, medicine, rat
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Neuro, Physiology and Pharmacology
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng
URI: http://discovery.ucl.ac.uk/id/eprint/10038809
Downloads since deposit
11Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item