UCL logo

UCL Discovery

UCL home » Library Services » Electronic resources » UCL Discovery

Sexually dimorphic effects of dietary sugar on lifespan, feeding and starvation resistance in Drosophila

Chandegra, B; Tang, JLY; Chi, H; Alic, N; (2017) Sexually dimorphic effects of dietary sugar on lifespan, feeding and starvation resistance in Drosophila. Aging , 9 (12) pp. 2521-2528. 10.18632/aging.101335. Green open access

[img]
Preview
Text
w3YiyiagABe2qePB3.pdf - ["content_typename_Published version" not defined]

Download (1MB) | Preview

Abstract

Lifespan and health in older age are strongly influenced by diet. Feeding Drosophila melanogaster diets high in sugar has increasingly been used as an experimental model to understand the physiological effects of unhealthy, contemporary human diets. Several metabolic parameters and physiological responses to nutrition are known to be dependent on the sex of the animal. However, sexual dimorphism in the responses to high‐ sugar diets in fruit flies has not been examined. Here we show that a high‐sugar diet in Drosophila melanogaster elicits sexually dimorphic effects on feeding behaviour, starvation resistance and lifespan. Females feed less on such diets, while males feed more, and these feeding responses may have secondary consequences. Females, more than males, gain the ability to resist periods of starvation from high‐sugar diets, indicating that the female response to excess sugar may be geared towards surviving food shortages in early life. At the same time, female lifespan is more susceptible to the detrimental effects of high sugar diets. Our study reveals differences between Drosophila sexes in their responses to sugar‐rich diets, indicating the fruit fly could be used as a model to understand the sexually dimorphic features of human metabolic health.

Type: Article
Title: Sexually dimorphic effects of dietary sugar on lifespan, feeding and starvation resistance in Drosophila
Open access status: An open access version is available from UCL Discovery
DOI: 10.18632/aging.101335
Publisher version: http://doi.org/10.18632/aging.101335
Language: English
Additional information: Chandegra et al. This is an open‐access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Genetics, Evolution and Environment
URI: http://discovery.ucl.ac.uk/id/eprint/10038762
Downloads since deposit
47Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item