UCL logo

UCL Discovery

UCL home » Library Services » Electronic resources » UCL Discovery

The Many Roles of Type II Phosphatidylinositol 4‐Kinases in Membrane Trafficking: New Tricks for Old Dogs

Minogue, S; (2018) The Many Roles of Type II Phosphatidylinositol 4‐Kinases in Membrane Trafficking: New Tricks for Old Dogs. BioEssays , 40 (2) , Article 1700145. 10.1002/bies.201700145.

[img] Text
s1-ln28246125-270170087-1939656818Hwf-1836341500IdV-144043819328246125PDF_HI0001.pdf - ["content_typename_Accepted version" not defined]
Access restricted to UCL open access staff until 28 December 2018.

Download (1MB)

Abstract

The type II phosphatidylinositol 4‐kinases (PI4KIIs) produce the lipid phosphatidylinositol 4‐phosphate (PtdIns4P) and participate in a confusing variety of membrane trafficking and signaling roles. This review argues that both historical and contemporary evidence supports the function of the PI4KIIs in numerous trafficking pathways, and that the key to understanding the enzymatic regulation is through membrane interaction and the intrinsic membrane environment. By summarizing new research and examining the trafficking roles of the PI4KIIs in the context of recently solved molecular structures, I highlight how mechanisms of PI4KII function and regulation are providing insights into the development of cancer and in neurological disease. I present an integrated view connecting the cell biology, molecular regulation, and roles in whole animal systems of these increasingly important proteins.

Type: Article
Title: The Many Roles of Type II Phosphatidylinositol 4‐Kinases in Membrane Trafficking: New Tricks for Old Dogs
DOI: 10.1002/bies.201700145
Publisher version: http://dx.doi.org/10.1002/bies.201700145
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: endosome, membrane trafficking, phosphatidylinositol 4‐kinase, sorting, TGN
URI: http://discovery.ucl.ac.uk/id/eprint/10037529
Downloads since deposit
2Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item