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Interactions between respiratory oscillators in adult rats.

Huckstepp, RT; Henderson, LE; Cardoza, KP; Feldman, JL; (2016) Interactions between respiratory oscillators in adult rats. Elife , 5 10.7554/eLife.14203.

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Abstract

Breathing in mammals is hypothesized to result from the interaction of two distinct oscillators: the preBötzinger Complex (preBötC) driving inspiration and the lateral parafacial region (pFL) driving active expiration. To understand the interactions between these oscillators, we independently altered their excitability in spontaneously breathing vagotomized urethane-anesthetized adult rats. Hyperpolarizing preBötC neurons decreased inspiratory activity and initiated active expiration, ultimately progressing to apnea, i.e., cessation of both inspiration and active expiration. Depolarizing pFL neurons produced active expiration at rest, but not when inspiratory activity was suppressed by hyperpolarizing preBötC neurons. We conclude that in anesthetized adult rats active expiration is driven by the pFL but requires an additional form of network excitation, i.e., ongoing rhythmic preBötC activity sufficient to drive inspiratory motor output or increased chemosensory drive. The organization of this coupled oscillator system, which is essential for life, may have implications for other neural networks that contain multiple rhythm/pattern generators.

Type: Article
Title: Interactions between respiratory oscillators in adult rats.
Location: England
DOI: 10.7554/eLife.14203
Keywords: neural microcircuits, neuroscience, parafacial lateral region, preBötzinger Complex, rat, respiration, respiratory oscillators, Animals, Biological Clocks, Exhalation, Inhalation, Neurons, Rats, Respiratory Center
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
URI: http://discovery.ucl.ac.uk/id/eprint/10036758
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