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Identification of leukotrienes in the sputum of patients with cystic fibrosis.

Cromwell, O; Walport, MJ; Taylor, GW; Morris, HR; O'Driscoll, BR; Kay, AB; (1982) Identification of leukotrienes in the sputum of patients with cystic fibrosis. Adv Prostaglandin Thromboxane Leukot Res , 9 pp. 251-257.

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Abstract

Sputum extracts from 16 of 25 adult patients with CF produced a slow, sustained contraction of isolated guinea pig ileum which was partially inhibitable by the SRS-A antagonist FPL 55712. Following progressive purification and HPLC, the major ileum-contracting substance was identified as LTD4. LTC4 was also present but in smaller amounts. The sputum contained other SRS-A-like activity which was not inhibited by FPL 55712; this substance was of a smaller molecular size than LTD4. The presence of LTB4 was also established using HPLC and an assay of neutrophil chemotaxis. These studies raise the possibility that leukotrienes and other lipoxygenase products may contribute to the progressive lung disease characteristics of CF.

Type: Article
Title: Identification of leukotrienes in the sputum of patients with cystic fibrosis.
Location: United States
Keywords: Adolescent, Adult, Animals, Arachidonic Acids, Biological Assay, Chemotaxis, Chromones, Cystic Fibrosis, Female, Guinea Pigs, Humans, Ileum, Leukotriene B4, Male, Muscle Contraction, Neutrophils, SRS-A, Sputum
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Inflammation
URI: http://discovery.ucl.ac.uk/id/eprint/10036736
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