UCL logo

UCL Discovery

UCL home » Library Services » Electronic resources » UCL Discovery

The tissue factor-factor VII complex: recent advances towards elucidating the structure and function of the initiator of haemostasis.

Tuddenham, EG; (1996) The tissue factor-factor VII complex: recent advances towards elucidating the structure and function of the initiator of haemostasis. Haemostasis , 26 Sup pp. 20-24. 10.1159/000217235.

Full text not available from this repository.

Abstract

Localised extravascular initiation of mammalian haemostasis is achieved by the anatomical localization of tissue factor (TF) around blood vessels and at organ surfaces. TF avidly binds factor VII from outflowing blood following vascular injury, forming the tissue factor/factor VII (TF.VII) complex. This is rapidly converted to TF.VIIa, the active initiator of blood coagulation. Structural studies have revealed that the extracellular region of TF consists of two C2-type immunoglobulin-like modules rigidly held at an angle of 125 degrees by an extensive buried interface. The regions of TF involved in binding factor VII extend from the binding finger of the domain interface across quite a wide surface of the distal (N-terminal) module. Solution scattering studies show that both TF and factor VII adopt an extended conformation in solution and that the complex is formed by a compact side by side alignment of the two proteins along their long axes.

Type: Article
Title: The tissue factor-factor VII complex: recent advances towards elucidating the structure and function of the initiator of haemostasis.
Location: Switzerland
DOI: 10.1159/000217235
Keywords: Amino Acid Sequence, Factor VII, Hemostasis, Humans, Models, Molecular, Molecular Sequence Data, Protein Structure, Tertiary, Structure-Activity Relationship, Thromboplastin
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Haematology
URI: http://discovery.ucl.ac.uk/id/eprint/10036182
Downloads since deposit
0Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item