Jahanshahi, M;
(2017)
Neuropsychological and Neuropsychiatric Features of Idiopathic and DYT1 Dystonia and the Impact of Medical and Surgical treatment.
Archives of Clinical Neuropsychology
, 32
(7)
pp. 888-905.
10.1093/arclin/acx095.
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Abstract
Dystonia is a hyperkinetic movement disorder, characterized by sustained or intermittent muscle contractions causing abnormal, often repetitive, movements, postures, or both. Executive dysfunction is a feature of cognitive function in idiopathic and DYT1 dystonia. Psychiatric morbidity is increased in dystonia, and depression, anxiety, obsessive compulsive disorders are the most common disorders. Sleep problems and pain are also frequently experienced. Evidence suggest that mood and anxiety disorders are intrinsic to the neurobiology of dystonia, but also that psychiatric co-morbidity can be secondary to pain experience and the psychosocial functioning and quality of life of the patients. Medical treatment of dystonia with botulinum toxin injections into affected muscles or with deep brain stimulation surgery improves the symptoms as well as mood and the quality of the patients and does not produce any adverse effects on cognitive function.
| Type: | Article |
|---|---|
| Title: | Neuropsychological and Neuropsychiatric Features of Idiopathic and DYT1 Dystonia and the Impact of Medical and Surgical treatment |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1093/arclin/acx095 |
| Publisher version: | http://dx.doi.org/10.1093/arclin/acx095 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Dystonia, Cognition, Psychiatric, Quality of life, Deep brain stimulation surgery, QUALITY-OF-LIFE, DEEP-BRAIN-STIMULATION, FOCAL HAND DYSTONIA, OBSESSIVE-COMPULSIVE DISORDER, PRIMARY CERVICAL DYSTONIA, PRIMARY GENERALIZED DYSTONIA, BOTULINUM TOXIN TREATMENT, SPASMODIC TORTICOLLIS, WRITERS CRAMP, PARKINSONS-DISEASE |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10035842 |
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