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A monoclonal antibody reactive with normal and leukemic human myeloid progenitor cells.

Griffin, JD; Linch, D; Sabbath, K; Larcom, P; Schlossman, SF; (1984) A monoclonal antibody reactive with normal and leukemic human myeloid progenitor cells. Leuk Res , 8 (4) pp. 521-534.

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Abstract

Anti-MY9 is an IgG2b murine monoclonal antibody selected for reactivity with immature normal human myeloid cells. The MY9 antigen is expressed by blasts, promyelocytes and myelocytes in the bone marrow, and by monocytes in the peripheral blood. Erythrocytes, lymphocytes and platelets are MY9 negative. All myeloid colony-forming cells (CFU-GM), a fraction of erythroid burst-forming cells (BFU-E) and multipotent progenitors (CFU-GEMM) are MY9 positive. This antigen is further expressed by the leukemic cells of a majority of patients with AML and myeloid CML-BC. Leukemic stem cells (leukemic colony-forming cells, L-CFC) from most patients tested were also MY9 positive. In contrast, MY9 was not detected on lymphocytic leukemias. Anti-MY9 may be a valuable reagent for the purification of hematopoietic colony-forming cells and for the diagnosis of myeloid-lineage leukemias.

Type: Article
Title: A monoclonal antibody reactive with normal and leukemic human myeloid progenitor cells.
Location: England
Keywords: Antibodies, Monoclonal, Antibodies, Neoplasm, Bone Marrow, Granulocytes, Hematopoietic Stem Cells, Humans, Leukemia, Myeloid, Acute, Monocytes
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Haematology
URI: http://discovery.ucl.ac.uk/id/eprint/10035767
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