UCL logo

UCL Discovery

UCL home » Library Services » Electronic resources » UCL Discovery

How many deficits in the same dyslexic brains? A behavioural and fMRI assessment of comorbidity in adult dyslexics

Danelli, L; Berlingeri, M; Bottini, G; Borghese, NA; Lucchese, M; Sberna, M; Price, CJ; (2017) How many deficits in the same dyslexic brains? A behavioural and fMRI assessment of comorbidity in adult dyslexics. Cortex , 97 pp. 125-142. 10.1016/j.cortex.2017.08.038. Green open access

[img]
Preview
Text (Accepted manuscript)
Danelli_Deficits_dyslexic_brains.pdf - ["content_typename_Accepted version" not defined]

Download (750kB) | Preview
[img]
Preview
Text (Tables)
Danelli_Deficits_dyslexic_brains_Suppl-tables.pdf

Download (368kB) | Preview
[img]
Preview
Text (Supplementary file: Figures)
Danelli_Deficits_dyslexic_brains_Suppl_figs.pdf

Download (3MB) | Preview
[img]
Preview
Text (Supplementary file: Behavioural tasks)
Danelli_Deficits_dyslexic_brains_Supplementary-materials.pdf

Download (213kB) | Preview
[img]
Preview
Text (Supplementary file: Behavioural results)
Danelli_Deficits_dyslexic_brains_Behavioural-results.pdf

Download (485kB) | Preview
[img]
Preview
Text (Supplementary file: PS Table 1)
Danelli_Deficits_dyslexic_brains_PSTable1.pdf

Download (129kB) | Preview
[img] Text (Supplementary file: Spreadsheet)
Danelli_Deficits_dyslexic_brains_Spreadsheet1.csv

Download (1kB)
[img] Text (Supplementary file: Spreadsheet)
Danelli_Deficits_dyslexic_brains_Spreadsheet2.csv

Download (1kB)
[img] Text (Supplementary file: Spreadsheet)
Danelli_Deficits_dyslexic_brains_Spreadsheet3.csv

Download (1kB)
[img] Text (Supplementary file: Spreadsheet)
Danelli_Deficits_dyslexic_brains_Spreadsheet4.csv

Download (1kB)
[img] Text (Supplementary file: Spreadsheet)
Danelli_Deficits_dyslexic_brains_Spreadsheet5.csv

Download (1kB)
[img] Text (Supplementary file: Spreadsheet)
Danelli_Deficits_dyslexic_brains_Spreadsheet6.csv

Download (1kB)
[img] Text (Supplementary file: Spreadsheet)
Danelli_Deficits_dyslexic_brains_Spreadsheet7.csv

Download (1kB)
[img] Text (Supplementary file: Spreadsheet)
Danelli_Deficits_dyslexic_brains_Spreadsheet8.csv

Download (1kB)
[img] Text (Supplementary file: Spreadsheet)
Danelli_Deficits_dyslexic_brains_Spreadsheet9.csv

Download (2kB)
[img] Text (Supplementary file: Spreadsheet)
Danelli_Deficits_dyslexic_brains_Spreadsheet10.csv

Download (1kB)
[img] Text (Supplementary file: Spreadsheet)
Danelli_Deficits_dyslexic_brains_Spreadsheet11.csv

Download (1kB)
[img] Text (Supplementary file: Spreadsheet)
Danelli_Deficits_dyslexic_brains_Spreadsheet12.csv

Download (1kB)

Abstract

Dyslexia can have different manifestations: this has motivated different theories on its nature, on its underlying brain bases and enduring controversies on how to best treat it. The relative weight of the different manifestations has never been evaluated using both behavioural and fMRI measures, a challenge taken here to assess the major systems called into play in dyslexia by different theories. We found that adult well-compensated dyslexics were systematically impaired only in reading and in visuo-phonological tasks, while deficits for other systems (e.g., motor/cerebellar, visual magnocellular/motion perception) were only very occasional. In line with these findings, fMRI showed a reliable hypoactivation only for the task of reading, in the left occipito-temporal cortex (l-OTC). The l-OTC, normally a crossroad between the reading system and other systems, did not show the same level of intersection in dyslexics; yet, it was not totally silent because it responded, in segregated parts, during auditory phonological and visual motion perception tasks. This minimal behavioural and functional anatomical comorbidity demonstrates that a specific deficit of reading is the best description for developmental dyslexia, at least for adult well-compensated cases, with clear implications for rehabilitation strategies. The reduced intersection of multiple systems in the l-OTC suggests that dyslexics suffer from a coarser connectivity, leading to disconnection between the multiple domains that normally interact during reading.

Type: Article
Title: How many deficits in the same dyslexic brains? A behavioural and fMRI assessment of comorbidity in adult dyslexics
Location: Italy
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.cortex.2017.08.038
Publisher version: https://doi.org/10.1016/j.cortex.2017.08.038
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Comorbidity, Developmental dyslexia, Disconnection hypothesis, Occipito-temporal cortex, fMRI
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Imaging Neuroscience
URI: http://discovery.ucl.ac.uk/id/eprint/10035526
Downloads since deposit
41Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item