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Red blood cell aggregate flux in a bifurcating microchannel

Kaliviotis, E; Pasias, D; Sherwood, JM; Balabani, S; (2017) Red blood cell aggregate flux in a bifurcating microchannel. Medical Engineering & Physics , 48 pp. 23-30. 10.1016/j.medengphy.2017.04.007.

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Abstract

Red blood cell aggregation plays a key role in microcirculatory flows, however, little is known about the transport characteristics of red blood cell aggregates in branching geometries. This work reports on the fluxes of red blood cell aggregates of various sizes in a T-shaped microchannel, aiming to clarify the effects of different flow conditions in the outlet branches of the channel. Image analysis techniques, were utilised, and moderately aggregating human red blood cell suspensions were tested in symmetric (∼50–50%) and asymmetric flow splits through the two outlet (daughter) branches. The results revealed that the flux decreases with aggregate size in the inlet (parent) and daughter branches, mainly due to the fact that the number of larger structures is significantly smaller than that of smaller structures. However, when the flux in the daughter branches is examined relative to the aggregate size flux in the parent branch an increase with aggregate size is observed for a range of asymmetric flow splits. This increase is attributed to size distribution and local concentration changes in the daughter branches. The results show that the flow of larger aggregates is not suppressed downstream of a bifurcation, and that blood flow is maintained, for physiological levels of red blood cell aggregation.

Type: Article
Title: Red blood cell aggregate flux in a bifurcating microchannel
Location: Politecnico Milano, Milan, ITALY
DOI: 10.1016/j.medengphy.2017.04.007
Publisher version: https://doi.org/10.1016/j.medengphy.2017.04.007
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Science & Technology, Technology, Engineering, Biomedical, Engineering, Blood flow, Red blood cell aggregate flux, Micro-PIV, Image processing techniques, IN-VIVO, ERYTHROCYTE AGGREGATION, RBC AGGREGATION, FLOW, VISCOSITY, VISCOELASTICITY, RHEOLOGY, HEMODYNAMICS, HEMATOCRIT, SHEAR
UCL classification: UCL > School of BEAMS
UCL > School of BEAMS > Faculty of Engineering Science
URI: http://discovery.ucl.ac.uk/id/eprint/10034079
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