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Regulation of developing myelin sheath elongation by oligodendrocyte calcium transients in vivo

Krasnow, AM; Ford, MC; Valdivia, LE; Wilson, SW; Attwell, D; (2018) Regulation of developing myelin sheath elongation by oligodendrocyte calcium transients in vivo. Nature Neuroscience , 21 pp. 24-28. 10.1038/s41593-017-0031-y. Green open access

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Abstract

How action potentials regulate myelination by oligodendrocytes is uncertain. We show that neuronal activity raises [Ca2+]i in developing oligodendrocytes in vivo and that myelin sheath elongation is promoted by a high frequency of [Ca2+]i transients and prevented by [Ca2+]i buffering. Sheath elongation occurs ~1 h after [Ca2+]i elevation. Sheath shortening is associated with a low frequency of [Ca2+]i transients but with longer duration [Ca2+]i bursts. Thus, [Ca2+]i controls myelin sheath development.

Type: Article
Title: Regulation of developing myelin sheath elongation by oligodendrocyte calcium transients in vivo
Open access status: An open access version is available from UCL Discovery
DOI: 10.1038/s41593-017-0031-y
Publisher version: http://dx.doi.org/10.1038/s41593-017-0031-y
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Cellular imaging, Oligodendrocyte
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Cell and Developmental Biology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Neuro, Physiology and Pharmacology
URI: http://discovery.ucl.ac.uk/id/eprint/10033977
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