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Determinants that increase the serum resistance of Escherichia coli.

Taylor, PW; Robinson, MK; (1980) Determinants that increase the serum resistance of Escherichia coli. Infect Immun , 29 (1) pp. 278-280.

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Abstract

The rfb locus, determining biosynthesis of O8-specific lipopolysaccharide side chains, was transferred to a rough mutant of Escherichia coli; recombinants producing a complete lipopolysaccharide were more resistant to the complement-mediated bactericidal action of human serum than the rough recipient. Inheritance of the his-linked genes for K27 antigen production did not alter the response to serum. The serum resistance of strains carrying O8 side chains, but not of strains with incomplete lipopolysaccharides, was further increased by inheritance of plasmids R1 and NR1.20

Type: Article
Title: Determinants that increase the serum resistance of Escherichia coli.
Location: United States
Keywords: Antigens, Bacterial, Blood Bactericidal Activity, Escherichia coli, Lipopolysaccharides, Plasmids, Recombination, Genetic
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy > Pharmaceutics
URI: http://discovery.ucl.ac.uk/id/eprint/10029853
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