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Classifying Proteins into Domain Structure Families

Cuff, A; Murzin, A; Orengo, C; (2013) Classifying Proteins into Domain Structure Families. In: Protein Families: Relating Protein Sequence, Structure, and Function. (pp. 37-68).

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Abstract

© 2014 John Wiley & Sons, Inc. This chapter reviews domain classifications with particular focus on the two most comprehensive protein structure classification resources-structural classification of proteins (SCOP) and class, architecture, topology, homology (CATH). It discusses general approaches to protein structure comparison, as well as methods used for recognizing domain boundaries. The classification hierarchies of both databases are reviewed and differences in the philosophies of the resources are discussed. The challenges that arise when classifying protein domain structures into superfamilies and the caveats that should be employed when assigning domains to the same fold group are explored. The chapter talks about the types of insights that can be gained into protein evolution from investigating diverse structural superfamilies. It also discusses the similarities and differences between the two resources, and ends with an introduction to the collaboration between CATH and SCOP, to provide consensus classifications via a new web portal, Genome3D.

Type: Book chapter
Title: Classifying Proteins into Domain Structure Families
ISBN-13: 9780470624227
DOI: 10.1002/9781118743089.ch3
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Structural and Molecular Biology
URI: http://discovery.ucl.ac.uk/id/eprint/10029175
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