UCL logo

UCL Discovery

UCL home » Library Services » Electronic resources » UCL Discovery

Myosin II Controls Junction Fluctuations to Guide Epithelial Tissue Ordering

Curran, S; Strandkvist, C; Bathmann, J; de Gennes, M; Kabla, A; Salbreux, G; Baum, B; (2017) Myosin II Controls Junction Fluctuations to Guide Epithelial Tissue Ordering. Developmental Cell 10.1016/j.devcel.2017.09.018. (In press). Green open access

[img]
Preview
Text
Curran_Myosin_II_Controls_Junction_Full.pdf - ["content_typename_Published version" not defined]

Download (15MB) | Preview

Abstract

Under conditions of homeostasis, dynamic changes in the length of individual adherens junctions (AJs) provide epithelia with the fluidity required to maintain tissue integrity in the face of intrinsic and extrinsic forces. While the contribution of AJ remodeling to developmental morphogenesis has been intensively studied, less is known about AJ dynamics in other circumstances. Here, we study AJ dynamics in an epithelium that undergoes a gradual increase in packing order, without concomitant large-scale changes in tissue size or shape. We find that neighbor exchange events are driven by stochastic fluctuations in junction length, regulated in part by junctional actomyosin. In this context, the developmental increase of isotropic junctional actomyosin reduces the rate of neighbor exchange, contributing to tissue order. We propose a model in which the local variance in tension between junctions determines whether actomyosin-based forces will inhibit or drive the topological transitions that either refine or deform a tissue.

Type: Article
Title: Myosin II Controls Junction Fluctuations to Guide Epithelial Tissue Ordering
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.devcel.2017.09.018
Publisher version: https://doi.org/10.1016/j.devcel.2017.09.018
Language: English
Additional information: This is an open access article under the CC BY IGO license (http://creativecommons.org/licenses/by/3.0/igo/).
Keywords: epithelia, morphogenesis, Myosin, cadherin, vertex model, neighbor exchange, junction fluctuations, tissue mechanics, tissue refinement, Drosophila
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
URI: http://discovery.ucl.ac.uk/id/eprint/10029070
Downloads since deposit
45Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item