Burnstock, G;
Knight, GE;
(2018)
The potential of P2X7 receptors as a therapeutic target, including inflammation and tumour progression.
Purinergic Signalling
, 14
(1)
pp. 1-18.
10.1007/s11302-017-9593-0.
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Abstract
Seven P2X ion channel nucleotide receptor subtypes have been cloned and characterised. P2X7 receptors (P2X7R) are unusual in that there are extra amino acids in the intracellular C terminus. Low concentrations of ATP open cation channels sometimes leading to cell proliferation, whereas high concentrations of ATP open large pores that release inflammatory cytokines and can lead to apoptotic cell death. Since many diseases involve inflammation and immune responses, and the P2X7R regulates inflammation, there has been recent interest in the pathophysiological roles of P2X7R and the potential of P2X7R antagonists to treat a variety of diseases. These include neurodegenerative diseases, psychiatric disorders, epilepsy and a number of diseases of peripheral organs, including the cardiovascular, airways, kidney, liver, bladder, skin and musculoskeletal. The potential of P2X7R drugs to treat tumour progression is discussed.
| Type: | Article |
|---|---|
| Title: | The potential of P2X7 receptors as a therapeutic target, including inflammation and tumour progression |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1007/s11302-017-9593-0 |
| Publisher version: | https://doi.org/10.1007/s11302-017-9593-0 |
| Language: | English |
| Additional information: | Copyright © The Author(s) 2017. Open Access: This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. |
| Keywords: | Pain; Infection; Cancer; CNS disorders; Cardiovascular; Airways; Diabetes; Kidney; Bladder; Liver; Gut; Immune cells |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10028750 |
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