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The finished DNA sequence of human chromosome 12

Scherer, SE; Muzny, DM; Buhay, CJ; Chen, R; Cree, A; Ding, Y; Dugan-Rocha, S; ... Gibbs, RA; + view all (2006) The finished DNA sequence of human chromosome 12. Nature , 440 (7082) pp. 346-351. 10.1038/nature04569.

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Abstract

Human chromosome 12 contains more than 1,400 coding genes 1 and 487 loci that have been directly implicated in human disease 2 . The q arm of chromosome 12 contains one of the largest blocks of linkage disequilibrium found in the human genome 3 . Here we present the finished sequence of human chromosome 12, which has been finished to high quality and spans approximately 132 megabases, representing ∼4.5% of the human genome. Alignment of the human chromosome 12 sequence across vertebrates reveals the origin of individual segments in chicken, and a unique history of rearrangement through rodent and primate lineages. The rate of base substitutions in recent evolutionary history shows an overall slowing in hominids compared with primates and rodents. © 2006 Nature Publishing Group.

Type: Article
Title: The finished DNA sequence of human chromosome 12
DOI: 10.1038/nature04569
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Institute of Cardiovascular Science
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Institute of Cardiovascular Science > Pre-clinical and Fundamental Science
URI: http://discovery.ucl.ac.uk/id/eprint/10028679
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