UCL logo

UCL Discovery

UCL home » Library Services » Electronic resources » UCL Discovery

Deprivation-Induced Homeostatic Spine Scaling In Vivo Is Localized to Dendritic Branches that Have Undergone Recent Spine Loss

Barnes, SB; Franzoni, E; Jacobsen, RI; Erdelyi, F; Szabo, G; Clopath, C; Keller, GB; (2017) Deprivation-Induced Homeostatic Spine Scaling In Vivo Is Localized to Dendritic Branches that Have Undergone Recent Spine Loss. Neuron , 96 (4) 871-882.e5. 10.1016/j.neuron.2017.09.052. Green open access

[img]
Preview
Text (Published article)
Barnes_Deprivation-Induced_Homeostatic_Spine.pdf - ["content_typename_Published version" not defined]

Download (3MB) | Preview
[img]
Preview
Text (Supplementary data)
Barnes_Deprivation-Induced_Homeostatic_Spine_Suppl1.pdf

Download (10MB) | Preview

Abstract

Synaptic scaling is a key homeostatic plasticity mechanism and is thought to be involved in the regulation of cortical activity levels. Here we investigated the spatial scale of homeostatic changes in spine size following sensory deprivation in a subset of inhibitory (layer 2/3 GAD65-positive) and excitatory (layer 5 Thy1-positive) neurons in mouse visual cortex. Using repeated in vivo two-photon imaging, we find that increases in spine size are tumor necrosis factor alpha (TNF-α) dependent and thus are likely associated with synaptic scaling. Rather than occurring at all spines, the observed increases in spine size are spatially localized to a subset of dendritic branches and are correlated with the degree of recent local spine loss within that branch. Using simulations, we show that such a compartmentalized form of synaptic scaling has computational benefits over cell-wide scaling for information processing within the cell.

Type: Article
Title: Deprivation-Induced Homeostatic Spine Scaling In Vivo Is Localized to Dendritic Branches that Have Undergone Recent Spine Loss
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.neuron.2017.09.052
Publisher version: https://doi.org/10.1016/j.neuron.2017.09.052
Language: English
Additional information: Copyright © 2017 The Author(s). Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Neuro, Physiology and Pharmacology
URI: http://discovery.ucl.ac.uk/id/eprint/10027751
Downloads since deposit
57Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item