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The relationship between prostacyclin activity and pressure in the portal vein.

Hamilton, G; Phing, RC; Hutton, RA; Dandona, P; Hobbs, KE; (1982) The relationship between prostacyclin activity and pressure in the portal vein. Hepatology , 2 (2) pp. 236-242.

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Abstract

The effect of portal hypertension (induced by partial ligation) on the ability of the portal vein wall to produce prostacyclin (PGI2) was studied in rats over a period of 6 weeks. PGI2-like activity measured by bioassay was shown to be significantly increased in portal vein segments during established hypertension when compared to control groups. As a collateral circulation developed with consequent fall in portal venous pressure, PGI2-like activity decreased. A positive correlation between PGI2-like activity and portal pressure has been demonstrated. Parallel measurements of this activity by bioassay and radioimmunoassay to 6-keto-prostaglandin-F1 alpha showed a positive correlation (r = 0.88) and suggested that PGI2 is the inhibitory prostaglandin involved. The possible significance of these observations in relation to the hemorrhagic manifestations associated with portal hypertension in man is discussed.

Type: Article
Title: The relationship between prostacyclin activity and pressure in the portal vein.
Location: United States
Keywords: Animals, Aspartate Aminotransferases, Blood Pressure, Epoprostenol, Hypertension, Portal, Portal Vein, Prostaglandins, Rats
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci
URI: http://discovery.ucl.ac.uk/id/eprint/10026937
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