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[Pharmacologic, surgical and infiltration of botulin toxin treatment in blepharospasm].

Grandas, F; Elston, J; Quinn, N; Marsden, CD; (1989) [Pharmacologic, surgical and infiltration of botulin toxin treatment in blepharospasm]. Neurologia , 4 (6) pp. 194-199.

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Abstract

The response to different therapeutic methods was evaluated in a series of 264 patients with blepharospasm. The most effective drug therapy were anticholinergic agents, which resulted in the initial improvement of symptoms in 20% of treated patients. There was improvement in isolated cases treated with levodopa, dopaminergic agonists, neuroleptics, benzodiazepines and tricyclic antidepressants. Bilateral avulsion of the facial nerve was carried out in 29 patients; 27 of these (93%) improved. Spasms relapsed in 22 cases, after a mean period of 12 months. Myectomy of the orbicular muscle was performed in 8 patients. In only 2 cases some improvement was obtained. One hundred and fifty-one patients were treated with infiltrations of botulinum toxin A in the orbicular muscle. 78% of cases improved. The mean duration of the benefit of each injection was 9.2 weeks. The most common secondary effects were local (ptosis, diplopia) and transient.

Type: Article
Title: [Pharmacologic, surgical and infiltration of botulin toxin treatment in blepharospasm].
Location: Spain
Keywords: Blepharospasm, Botulinum Toxins, Evaluation Studies as Topic, Eyelid Diseases, Humans, Injections, Intramuscular, Prospective Studies, Retrospective Studies
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
URI: http://discovery.ucl.ac.uk/id/eprint/10026657
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