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The kinetics and thermodynamics of the reduction of cytochrome c by substituted p-benzoquinols in solution.

Rich, PR; Bendall, DS; (1980) The kinetics and thermodynamics of the reduction of cytochrome c by substituted p-benzoquinols in solution. Biochim Biophys Acta , 592 (3) pp. 506-518. 10.1016/0005-2728(80)90095-x.

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Abstract

1. The mechanisms by which p-benzoquinol and its derivatives reduce cytochrome c in solution have been investigated. 2. The two major reductants are the species QH- (anionic quinol) and Q.- (anionic semiquinone). A minor route of electron transfer from the fully protonated QH2 species can also occur. 3. The relative contributions of these routes to the overall reduction rate are governed by pH, ionic strength and relative reactant concentrations. 4. For a series of substituted p-benzoquinols, the forward rate constant, k1, of the anionic quinol-mediatd reaction is related to the midpoint potential of the QH-/QH. couple involved in the rate-limiting step, as predicted by the theory of Marcus for outer-sphere electron transfer reactions in a bimolecular collision process. 5. A mechanism for the biological quinol oxidation reactions in mitochondria and chloroplasts is proposed based upon the findings with these reactions in solution.

Type: Article
Title: The kinetics and thermodynamics of the reduction of cytochrome c by substituted p-benzoquinols in solution.
Location: Netherlands
DOI: 10.1016/0005-2728(80)90095-x
Keywords: Animals, Anions, Benzoquinones, Cytochrome c Group, Free Radicals, Horses, Hydroquinones, Kinetics, Mathematics, Osmolar Concentration, Oxidation-Reduction, Quinones, Thermodynamics
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Structural and Molecular Biology
URI: http://discovery.ucl.ac.uk/id/eprint/10026569
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