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Cytomegalovirus pneumonitis complicated by a central peribronchial pattern of organising pneumonia

Cuadrado, MM; Ahmed, A; Carpenter, B; Brown, JS; (2017) Cytomegalovirus pneumonitis complicated by a central peribronchial pattern of organising pneumonia. Respiratory Medicine Case Reports , 20 pp. 184-187. 10.1016/j.rmcr.2017.02.005. Green open access

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Abstract

We present five cases of cytomegalovirus (CMV) pneumonitis occurring in patients after recent T cell deplete allogeneic stem cell transplantation (AlloHSCT). These cases were complicated by an organising pneumonia (during the recovery period) with a predominantly central peribronchial pattern. All patients presented with evidence of active CMV pneumonitis which was treated successfully with anti-viral therapy but was followed by persistent severe dyspnoea, cough and hypoxia. High resolution computed tomography (HRCT) imaging showed widespread central peribronchial consolidation with traction bronchiectasis. There was a marked clinical and physiological improvement after treatment with systemic corticosteroids. However, in all patients the lung function remained abnormal and in some cases imaging revealed a fibrosing lung disease. These cases represent a previously undescribed central peribronchial pattern of organising pneumonia complicating CMV pneumonitis that can result in chronic lung damage.

Type: Article
Title: Cytomegalovirus pneumonitis complicated by a central peribronchial pattern of organising pneumonia
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.rmcr.2017.02.005
Publisher version: https://doi.org/10.1016/j.rmcr.2017.02.005
Language: English
Additional information: This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit https://creativecommons.org/licenses/by-nc-nd/4.0/
Keywords: Organising pneumonia, Cytomegalovirus pneumonitis, Allogeneic stem cells transplantation (AlloHSCT)
UCL classification: UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Respiratory Medicine
URI: http://discovery.ucl.ac.uk/id/eprint/10026019
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