Contarino, MF;
Van den Dool, J;
Balash, Y;
Bhatia, K;
Giladi, N;
Koelman, JH;
Lokkegaard, A;
... Tijssen, MAJ; + view all
(2017)
Clinical Practice: evidence-Based Recommendations for the Treatment of Cervical Dystonia with Botulinum Toxin.
[Review].
Frontiers in Neurology
, 8
(35)
10.3389/fneur.2017.00035.
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Abstract
Cervical dystonia (CD) is the most frequent form of focal dystonia. Symptoms often result in pain and functional disability. Local injections of botulinum neurotoxin are currently the treatment of choice for CD. Although this treatment has proven effective and is widely applied worldwide, many issues still remain open in the clinical practice. We performed a systematic review of the literature on botulinum toxin treatment for CD based on a question-oriented approach, with the aim to provide practical recommendations for the treating clinicians. Key questions from the clinical practice were explored. Results suggest that while the beneficial effect of botulinum toxin treatment on different aspects of CD is well established, robust evidence is still missing concerning some practical aspects, such as dose equivalence between different formulations, optimal treatment intervals, treatment approaches, and the use of supportive techniques including electromyography or ultrasounds. Established strategies to prevent or manage common side effects (including excessive muscle weakness, pain at injection site, dysphagia) and potential contraindications to this treatment (pregnancy and lactation, use of anticoagulants, neurological comorbidities) should also be further explored.
| Type: | Article |
|---|---|
| Title: | Clinical Practice: evidence-Based Recommendations for the Treatment of Cervical Dystonia with Botulinum Toxin |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.3389/fneur.2017.00035 |
| Publisher version: | https://doi.org/10.3389/fneur.2017.00035 |
| Language: | English |
| Additional information: | © 2017 Contarino, Van Den Dool, Balash, Bhatia, Giladi, Koelman, Lokkegaard, Marti, Postma, Relja, Skorvanek, Speelman, Zoons, Ferreira, Vidailhet, Albanese and Tijssen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
| Keywords: | Science & Technology, Life Sciences & Biomedicine, Clinical Neurology, Neurosciences, Neurosciences & Neurology, Botulinum Toxin, Cervical Dystonia, Recommendations, Efficacy, Side Effects, Treatment Strategy, Selective Peripheral Denervation, Placebo-Controlled Trial, Long-Term Treatment, Double-Blind, Spasmodic Torticollis, Myasthenia-Gravis, Neutralizing Antibodies, Secondary Nonresponse, Therapy Failure, Parallel-Group |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Movement Neurosciences |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10024744 |
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