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Compartmentalized Signaling in Neurons – from Cell Biology to Neuroscience

Terenzio, M; Schiavo, G; Fainzilber, M; (2017) Compartmentalized Signaling in Neurons – from Cell Biology to Neuroscience. Neuron (In press).

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Abstract

Neurons are the largest known cells, with complex and highly polarized morphologies. As such, neuronal signaling is highly compartmentalized, requiring sophisticated transfer mechanisms to convey and integrate information within and between sub-neuronal compartments. Here we survey different modes of compartmentalized signaling in neurons, highlighting examples wherein the fundamental cell biological processes of protein synthesis and degradation, membrane trafficking, and organelle transport are employed to enable the encoding and integration of information, locally and globally within a neuron. Comparisons to other cell types indicate that neurons accentuate widely shared mechanisms, providing invaluable models for the compartmentalization and transfer mechanisms required and used by most eukaryotic cells.

Type: Article
Title: Compartmentalized Signaling in Neurons – from Cell Biology to Neuroscience
Publisher version: http://www.cell.com/neuron/home
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Neurotrophin, importin, receptor tyrosine kinase, axonal transport, local translation, mRNA localization
UCL classification: UCL > School of Life and Medical Sciences
UCL > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Neurology
URI: http://discovery.ucl.ac.uk/id/eprint/10024649
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