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Compartmentalized Signaling in Neurons: From Cell Biology to Neuroscience

Terenzio, M; Schiavo, G; Fainzilber, M; (2017) Compartmentalized Signaling in Neurons: From Cell Biology to Neuroscience. Neuron , 96 (3) pp. 667-679. 10.1016/j.neuron.2017.10.015.

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Neurons are the largest known cells, with complex and highly polarized morphologies. As such, neuronal signaling is highly compartmentalized, requiring sophisticated transfer mechanisms to convey and integrate information within and between sub-neuronal compartments. Here, we survey different modes of compartmentalized signaling in neurons, highlighting examples wherein the fundamental cell biological processes of protein synthesis and degradation, membrane trafficking, and organelle transport are employed to enable the encoding and integration of information, locally and globally within a neuron. Comparisons to other cell types indicate that neurons accentuate widely shared mechanisms, providing invaluable models for the compartmentalization and transfer mechanisms required and used by most eukaryotic cells.

Type: Article
Title: Compartmentalized Signaling in Neurons: From Cell Biology to Neuroscience
DOI: 10.1016/j.neuron.2017.10.015
Publisher version: https://doi.org/10.1016/j.neuron.2017.10.015
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: neurotrophin, importin, receptor tyrosine kinaseaxonal transport, local translation, mRNA localization, dyneinkinesin, microtubule, subcellular
URI: http://discovery.ucl.ac.uk/id/eprint/10024649
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