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Statins as anti-inflammatory agents: A potential therapeutic role in sight-threatening non-infectious uveitis

Gilbert, R; Al-Janabi, A; Tomkins-Netzer, O; Lightman, S; (2017) Statins as anti-inflammatory agents: A potential therapeutic role in sight-threatening non-infectious uveitis. Porto Biomedical Journal , 2 (2) pp. 33-39. 10.1016/j.pbj.2017.01.006. Green open access

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Abstract

In addition to the known lipid-lowering effects, statins are now widely accepted to have antiinflammatory and immunomodulatory effects. Adjunctive use of statins has proven beneficial in the context of a wide range of inflammatory diseases, including rheumatoid arthritis. Evidence also suggests that statins may also have utility in the management of uveitis, a form of sight threatening inflammation which occurs in the eye. In this article, we outline our rationale behind a clinical trial of simvastatin as a steroid-sparing agent in uveitis, to which patient recruitment started last year. Potential risks associated with the clinical use of statins, including putative effects on the eyes, are discussed.

Type: Article
Title: Statins as anti-inflammatory agents: A potential therapeutic role in sight-threatening non-infectious uveitis
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.pbj.2017.01.006
Publisher version: http://doi.org/10.1016/j.pbj.2017.01.006
Language: English
Additional information: Copyright © 2017 PBJ-Associac¸ ao˜ Porto Biomedical/Porto Biomedical Society. Published by Elsevier Espana, ˜ S.L.U. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
Keywords: Uveitis, Statins, Ocular inflammatory disease, Steroid-sparing agents, Anti-inflammatory
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Ophthalmology
URI: https://discovery.ucl.ac.uk/id/eprint/10022861
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