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Physical Activity and Improvement of Glycaemia in Pre-diabetes by Different Diagnostic Criteria

Færch, K; Witte, DR; Brunner, E; Kivimäki, M; Tabak, A; Jørgensen, ME; Ekelund, U; (2017) Physical Activity and Improvement of Glycaemia in Pre-diabetes by Different Diagnostic Criteria. The Journal of Clinical Endocrinology & Metabolism , 102 (10) pp. 3712-3721. 10.1210/jc.2017-00990. Green open access

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Abstract

CONTEXT: The effects of physical activity (PA) on improvement of glycaemia may differ between pre-diabetic individuals defined by OGTT versus HbA1c. OBJECTIVE: We studied the association between PA and improvement of glycaemia in individuals with pre-diabetes defined by glucose versus HbA1c criteria. DESIGN, SETTING AND PARTICIPANTS: From the Whitehall II study, 957 participants with pre-diabetes defined by isolated impaired fasting glucose (i-IFG), isolated impaired glucose tolerance (IGT) or both (IFG+IGT), and 457 with pre-diabetes defined by HbA1c were included. MAIN OUTCOME MEASURES: The associations of PA with concomitant changes in glucose-related outcomes during 5-years of follow-up were analysed. A recursive partitioning analysis was performed to study heterogeneity in the association between baseline PA and the probability of reversion to normoglycaemia. RESULTS: After 5-years of follow-up, 405 (42%) individuals with glucose-defined pre-diabetes reverted to NGT. A 5-year increase in moderate-to-vigorous-intensity PA was associated with improvements in insulin sensitivity and beta-cell function, but PA was not generally associated with reversion to NGT. Only among women ≥50 years with i-IFG or i-IGT, higher amounts of PA were associated with higher probability of reversion to NGT. In HbA1c-defined pre-diabetes, only 20 individuals (4.4%) reverted to normoglycaemia, and PA was not associated with improvement in glycaemic markers. CONCLUSIONS: PA may be particularly important for reversion to normoglycaemia in older women with i-IFG or i-IGT. Individuals with pre-diabetes identified by HbA1c have a low probability of reversion to normoglycaemia, and their changes in glycaemia are not related to PA.

Type: Article
Title: Physical Activity and Improvement of Glycaemia in Pre-diabetes by Different Diagnostic Criteria
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1210/jc.2017-00990
Publisher version: http://dx.doi.org/10.1210/jc.2017-00990
Language: English
Additional information: This article has been published under the terms of the Creative Commons Attribution License (CC BY; https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Copyright for this article is retained by the author(s).
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Institute of Epidemiology and Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Institute of Epidemiology and Health > Epidemiology and Public Health
URI: http://discovery.ucl.ac.uk/id/eprint/10022832
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